Researchers from the Gladstone Institutes, USA, managed to obtain stem cells from skin cells, by activating just one gene in the cells using CRISPR technology. The innovative method, published on January 18, 2018 in Cell Stem Cell, offers a potentially simpler technique to produce the valuable cell type and reveals important information about the process of cellular reprogramming process.
A new study by American scientists from the Florida campus of The Scripps Research Institute (TSRI) identifies factors that play a key role in the differentiation of mesenchymal stem cells. The results, published on January 8, 2018 in Cell Death & Differentiation, will help improve the methods of using these cells in clinical practice.
Teams of the University of California - Los Angeles (UCLA) Health Sciences , USA, for the first time were able to turn human stem cells into sensory interneurons, responsible for the sense of touch. The technique, published January 11, 2018 in Stem Cell Reports, could be become the basis of stem cell therapy, which will help restore sensitivity in paralyzed patients.
Researchers from Duke University, USA, have grown the first functioning muscle from stem cells derived from reprogrammed human skin cells. The new technique described in the article, which was published on January 9, 2018 in Nature Communications, will help scientists to expand the capabilities of cell therapy, and to develop individual models of rare diseases of muscle tissue for drug discovery and biological research.
Scientists from the University of North Carolina (UNC), USA, have discovered a specific cluster that helps unwind DNA strands during cell division and plays a key role in stem cells in the immature state. The results of the study are published in the journal eLife.
Scientists from the Cincinnati Children's Hospital Medical Center, CCHMC, USA, have found a negative obesity effect on the long-term health of hematopoietic stem cells in mice. The results of the study were published on December 27, 2017 in The Journal of Experimental Medicine.
Scientists from the Helmholtz Zentrum München (German Research Center for Environmental Health) identified a specific population of pluripotent embryonic stem cells that can reprogram into totipotent-like cells in culture. Moreover, researchers, who published an article with the results on December 18, 2017 in Nature Genetics, determined the factors and mechanism of this reprogramming.
Researchers at the Buck Institute for Research on Aging, USA, found that treating mice with the TOR-inhibitor rapamycin prevented the loss of adult stem cells and could reverse age-related loss of stem cells in mouse trachea. The results of the study were published on December 7, 2017 in Cell Stem Cell.
A team of scientists and clinicians from Lund University in Sweden developed a multi-stage method that allows the safe collection of a large number of mesenchymal stem cells from the amniotic fluid. The results of the study are published in Stem Cell Research & Therapy.