Tuesday, 11 June 2013 18:51

Diabetes

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Stem cells and diabetesStem cells and diabetes

A large number of people around the world are currently exposed to such severe and insidious diseases as diabetes. The disease begins unnoticed - with minor violation of urination and unusual thirst. Over time, these health problem occur, which can even result in death.

Diabetes can lead to many serious diseases that are associated with cardiac activity, functions of the vessels, liver, nervous system, etc. The main symptom of diabetes is either high or low blood sugar levels compared with those of a healthy person.

Unfortunately, the drugs used to treat diabetes, often adversely affect the work of the heart. The solution to this problem is using a new method of effective treatment of diabetes such as cell therapy with the use of autologous (own) stem cells. This does not eliminate the effects of low blood glucose level of the patient, but directly the cause of the disease.

The benefit of stem cells is their amazing ability to regenerate organs and tissues. This helps to restore normal operation of the pancreas and consequently the blood sugar level.

Treatment of diabetes with stem cells

Diabetes of both types is treated by 3 multiple intravenous administration of stem cells at certain intervals. In case of "diabetic foot" an additional injection is administered to the affected tissues of the limb. Cell injection protocol coincides with the standard protocol of intravenous drugs.

Scheme of treating diabetes I and II types

  • In the first step an amount of adipose tissue of the patient is extracted. The procedure lasts about 30 minutes and is performed under local anesthesia. To eliminate possible complications the patient rests under the supervision of a doctor at the clinic for a day.
  • The second step consists of examination of the patient by a doctor, and discharging him home. The required amount of stem cells of the patient is reached within 3-4 weeks of cultivation.
  • In the third step the patient is invited to the clinic and receives an intravenous injection of autologous stem cells from the adipose tissue collected previously. The whole procedure takes about 10-15 minutes. The patient returns home, where he spends two weeks waiting for the next dose of stem cells.
  • The fourth and fifth steps consist of similar injections every 2 weeks.
  • In case of the most severe forms of diabetes a sixth step is advised, which includes an additional injection.
  • The seventh step is the ability to store the cells in the Cryobank. In liquid nitrogen cells can be conserved for 15 to 20 years. If necessary, the cells can be taken from the Cryobank and provided to the patient after two weeks of cultivating to the required therapeutic dose. Storage of a therapeutic dose in the Cryobank and its provision to the patient in the desired moment is also possible. The cost of storage does not affect what dose of cells is conserved - the initial or therapeutic.

Cell treatment in the laboratory

The laboratory is equipped with modern facilities and is fully compliant with international standards GCP, GLP. A sample of adipose tissue in a sterile form arrives in the laboratory in compliance with the protocols GCP. Testing of the cells and determination of their quality is performed. Further, in order to obtain therapeutic doses, cells are cultivated under continuous strict control.

Restrictions on the use of stem cells

Stem cells may be exposed to bacterial and viral infections. For this reason they cannot be administered to patients with ongoing infectious processes (marked by high temperature). Such patients must be pretreated by conventional medical methods. In case of diabetic peripheral angiopathy in the patient his own stem cells have to be injected intramuscularly at a minimum distance from the lesion.The efficacy of treatment with stem cells.

The efficacy of treatment with stem cells

The result of the treatment with stem cells in adults depends on the literacy of the biotechnological laboratory and the responsible approach to treatment of the patient. In many cases patients experience significant improvement until complete recovery as a result of the treatment with their own stem cells. Sometimes the effect of treatment is small and spread over time, but it still available.

A summary of the results of clinical trials for the treatment of diabetes type I and II

Limited clinical trials for the treatment of diabetes with stem cells were carried out. The tests were conducted at the Central Military Clinical Hospital of the Armed Forces of Ukraine. The control was exercised by the Ministry of Defense and the Ministry of Health of Ukraine.
Below is a graph showing the relation of the blood glucose levels in patients on the number of injections. The experiment involved 48 patients of different age categories. The control group received saline while the test group - autologous mesenchymal stem cells from their own adipose tissue. As seen from the graph, in contrast to the control group, the experimental group blood glucose levels have returned to normal as a result of cell therapy.

 diagram below shows a level of blood sugar

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